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For anything except source code: Arial (Helvetica). I think serifs are the typeface equivalent of training wheels, and about as useful as tits on a boar.
Source code: Consolas. I switch back and forth occasionally between Courier New and Consolas. Let the "Oh, that's so old school! I use 'Gorgenfragits Light with a Twist of Lemon', and it's perfect for coding" discussions begin.
I thought Comic Sans was cute, until I found that one of the asshats I deal with in the home office uses it. Uses it as the default font in all his e-mails, including those sent outside the company. In blue.
Any font that makes it easy to distinguish 6, 8 and 9 from each other, and 1, l, I from each other, and 0, O from each other. I think I found one such font, but forgot what it was. Now, I'll have to go look for it. It's time to start considering aUI, the language of space.
I've been burnt by the 0 and O. Took me days to find it. Finally I copied my code and pasted it into an email to someone I was asking for help from...the email program used a different font that displayed the 0 and O differently. That one is definately a bugger. But I like a fixed-width font when coding, and I don't know of one that is both fixed-width and distinguishes those characters nicely.
There are such fonts, because I've seen lots of zeros with slashes through them to distinguish them from Ohs. I'll have to start a major search and add a page to my documentation about which fonts do what.