I expect the clients becoming smaller, cheaper, dumber; and the real value of the apps to reside on servers (no Metro there), clouds or other. Bandwidth increasing all the time, we won't continue to carry around big apps. Web services, or whatever fancy name will be in vogue then, and pretty simple client stuff, mostly presentation layer. What client software remains is a browser, some social networking items perhaps, and a lot of gadgetry. We won't be running ERP or SAP locally.
A conversation where the MS rep is asked: what's Metro going to do for us ?
So once more the MS answer will be: everything you need.