As CodeProject is mostly a Windows centric site I assume that you are looking for a solution that works on Windows - so have a look at: PyHook
Description from the project site:
pyHook is a python wrapper for global input hooks in Windows. Specifically it wraps the Windows SetWindowsHookEx API function using low-level keyboard (WH_KEYBOARD_LL) and mouse (WH_MOUSE_LL) hooks.
The pyHook package provides callbacks for global mouse and keyboard events in Windows. Python applications register can event handlers for user input events such as left mouse down, left mouse up, key down, etc. and set the keyboard and/or mouse hook. The underlying C library reports information like the time of the event, the name of the window in which the event occurred, the value of the event, any keyboard modifiers, etc. Events can be logged and/or filtered.