You can do it...but it's not easy, particularly if you don't store skills in any particular order. You can use the LIKE condition to pick up one skill:
SELECT name FROM myTable WHERE skills LIKE '%.net%'
would pick up both lines, but for multiple skills it's a PITA.
I would change the way you stored skills - have a Skills table, which has a name (".NET", "Java", ...) and an ID, then have a separate table linking the client to a skill (via the client ID). THis way, you can retrieve all those who have multiple skills much, much =more efficiently (And you can't spell "java" as "jova" by mistake when doing data entry and miss some one out for a position)