Try this :
Private Sub PictureBox1_Click(sender As System.Object, e As System.EventArgs) Handles PictureBox1.Click
PictureBox1.Image = Image.FromFile("c:\myImage.jpg")
I created a new project with one form, added a PictureBox with an image set at the image field from the properties of that PictureBox. Then added that sc up there just to change the image from file.