Yes, you can.
There are several fairly stable .net wrappers for ffmpeg.
] and the tao framework
] (tao site appears to be down right now, so I don't know what's going on with this project, but it seemed all fine a few months ago, the The wikipedia page
]) doesn't mention any closure). You can still download the bits from their sourceforge page
Both of these projects are open source so you can check out the code as a sample if you would rather do things yourself.