By default web site has a user assigned to it with minimal right, just for running the site itself. For sure instantiating COM/DCOM object is forbidden. And I do not advise you to change the users rights...
In any case you approach seems to me wrong from the beginning. Microsoft offers the
VSTO[
^] package to handle office files from code, even without Office installed! Go and learn it, than use it for your web application!