Break Point has not fired in button_Click event.

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C#

C#4.0

Dear sir,
In this project I'm facing a problem. In this page the I couldn't reached at the button click event. The breakpoints hits at the page load, but not working any of the buttons and so code has not executed at the run time.
In the Design Part:

<asp:Button ID="btnSubmit" runat="server" Text="Submit"
          CssClass="btn" onclick="btnSubmit_Click1" />
          <asp:Button
          ID="btnCancel" runat="server" Text="Cancel" CssClass="button"
          onclick="btnCancel_Click" />

In the Code Part:

protected void Page_Load(object sender, EventArgs e)
    {
       // lblMsg.Text = "Data submitted successfully...";
    }

protected void btnSubmit_Click1(object sender, EventArgs e)
   {
       lblMsg.Text = "Data inserted successfully...";
   }
   protected void btnCancel_Click(object sender, EventArgs e)
   {
       resetText();
   }

I found that the error is in my Master Page. When I add a new page excluding Master Page all the thing are worked fine and when I add it through Master page then button click event does not fire, So what is the error in Master Page I could not found.