What sort of brushes do you want to create ? I wrote a GDI+ article ages ago ( although it may be in c++ ) covering the different types of brushes.
wrote:2.) How can I get the actual image coordinates by clicking on it?
Your best bet is to draw your own image in your paint event, so that you are responsible for any resizing that occurs, and can therefore reverse that algorithm to convert a point in the image on screen to that point in the actual image.
Pictureboxes are not really compatible with image processing.