How to disable subsequent submit button clicks when a request is being processed in ASP.NET AJAX client side script code

Atul works at Microsoft as a .NET consultant. As a consultant his job is to design, develop and deploy enterprise level secure and scalable solutions using Microsoft Technologies.
 
His technical expertise include .NET Framework(4.0, 3.5, 3.0), WPF, WCF, SharePoint 2010, ASP.net, AJAX, Web Services, Enterprise Applications, SQL Server 2008, Open Xml, MS Word Automation.
 
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He blogs at
http://www.atulverma.com
http://blogs.msdn.com/b/atverma