How to run a .exe from chrome browser using javascript?

See more:

Java

SAP

chrome

Hi,
I have been trying to run an exe from a browser using Java Script. Below is the code I have been using for WindowsIE.

var MyObject = new ActiveXObject( "WScript.Shell" )
function RunExe()
{
MyObject.Run("file:///C:/Program%20Files/EditPlus%203/editplus.exe") ;
}

Can anyone tell me how to do the same using Chrome/FireFox with out any pop-ups. I know that the basic difference between IE and others is that IE uses ActiveX and others use NPAPI/runtime to install Plugins.

Any suggestions would help

Thanks
Rahul

What I have tried:

var MyObject = new ActiveXObject( "WScript.Shell" )
function RunExe()
{
MyObject.Run("file:///C:/Program%20Files/EditPlus%203/editplus.exe") ;
}