Expanding on Amits solution:
foreach (string emailCC in txtCc.Text.ToString().Split(splitter))
{
if(!string.IsNullOrWhitespace(emailCC)){
mail.CC.Add(new MailAddress(emailCC.Trim()));
}
}
or, you can catch it earlier by using one of the .Split overloads:
foreach (string emailCC in txtCc.Text.ToString().Split(splitter.ToCharArray(), StringSplitOptions.RemoveEmptyEntries))