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The delta-v from LEO to mars transfer orbit is "only" 4.3 km/s when compared to the 9.3 km/s it takes to get from earth to LEO. But you'd be surprised at how much more fuel you would need for that.
It's a fairly simple differential equation if you're interested to calculate it yourself.
But if you're interested in numbers from better people than me, the mars vehicle that SpaceX is planning will weigh 3.5 times more than the Saturn 5. Which is slightly more than just "modern enhancements".