Buttons inside user controls are not working

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ASP.NET

I have implemented 3 user controls to on page. The page has a master page also. All the three user controls has its own buttons and validations. I created a break point on the code behind of the button click. When I click on the the button the break point is not triggering. This issue is exist for all the buttons inside the user controls of the the page.

Here is my aspx code for one control.

<div class="col-sm-2 col-xs-12 cart-border-right">
                  <span class="visible-xs span-data-item">Quantity : </span>
                    <div class="input-group btn-block">
                      <asp:TextBox ID="txtQty" runat="server" MaxLength="2" CssClass="form-control" Text="1" ValidationGroup="s" />
                <asp:FilteredTextBoxExtender ID="fte1" runat="server" FilterType="Numbers" TargetControlID="txtQty"></asp:FilteredTextBoxExtender>
                      <span class="input-group-btn">
                      <asp:LinkButton ID="lnkUpdate" runat="server" OnClick="lnkUpdate_Click" ValidationGroup="s" CausesValidation="true"
                          data-toggle="tooltip" title="" data-original-title="Update" CssClass="btn btn-primary"><i class="fa fa-refresh"></i></asp:LinkButton>
                      <asp:LinkButton ID="btnRemove" runat="server" OnClick="btnRemove_Click" ValidationGroup="s" CausesValidation="true"
                          data-toggle="tooltip" title="" data-original-title="Remove" CssClass="btn btn-primary"><i class="fa fa-times-circle"></i></asp:LinkButton>
                      </span></div>
                  </div>

Please help me to fix this issue. Thanks in advance.