Use Copy method and remove desired columns
DataTable newTable ;
newTable = dt.Copy();
or you can clone datatable structure and by looping add rows to new table
DataTable newTable = dt.Clone();
foreach (DataRow item in dt.Rows)
{
newTable.ImportRow(item);
}
for column removal use one of below
dt.Columns.Remove("columnName");
dt.Columns.RemoveAt(columnIndex);
Updated solution:
DataTable dt = new DataTable();
dt.Columns.Add("[Serial Number]", typeof(int));
dt.Columns.Add("[Last Name]", typeof(string));
dt.Columns.Add("[First Name]", typeof(string));
dt.Columns.Add("Salary", typeof(decimal));
dt.Columns.Add("[Mobile No]", typeof(string));
dt.Rows.Add(1, "Kulkarni", "Ramesh", 1500.00, "9485234567");
dt.Rows.Add(2, "rani", "suresh", 1500.00, "9485234567");
DataTable newTable;
newTable = dt.Copy();
newTable.Columns.Remove("[Mobile No]");
newTable.AcceptChanges();