Yes you can take the help of FCKEditor. Here is the code.
Put FCKEdItor in design page.
<FCKeditorV2:FCKeditor ID="FCKeditor1" runat="server" BasePath="~/fckeditor1/">
</FCKeditorV2:FCKeditor>
In your code behind you can use this FCKeditor value like this :-
mail.Body = FCKeditor1.Value.ToString();
For all this you have to take the reference of FredCK.FCKeditorV2.dll