in the System.Drawing.Bitmap object you can use the GetPixel(x, y) to find the color of a pixel.
Bitmap bmp = new Bitmap(@"C:\test.bmp");
for (int x = 0; x < 151; x++)
for (int y = 500; y < 1001; y++)
if (bmp.GetPixel(x, y).ToArgb() == Color.Black.ToArgb())
MessageBox.Show("I found black!");