First, use the
SerialPort class[
^] - the link includes an example.
Second, check your com port connection to the device: if it's a "real" COM port rather than a USB connection then some devices require control signals such as RTS/CTS and DTR before they can start to talk.
You also need to check the speed, bits per character, stop bits, and parity are correct, and that the device doesn't need to you "talk first" before it sends any data.
I'd recommend checking the connection first using hyperterminal or similar before moving direct to code with all the possibilities for other mistakes that adds.