Please see my comment to this question — I don't think it's really fruitful. Maybe you could pay attention for all other Python GUI frameworks and ask an advice on what to use to meet certain development goals:http://wiki.python.org/moin/GuiProgramming
As you can see, some of the frameworks use TkInter as a target.
(Sorry, please don't ask me which is better to use, as I never tried any.)—SA