Whichever number is greater, subtract the other number from it ;)
You can do something like this,
ran1 = randint(0,20)
ran2 = randint(0,20)
if ran1 > ran2
print('What is ' + str(ran1) + ' - ' + str(ran2) + '?')
elif ran2 > ran1
print('What is ' + str(ran2) + ' - ' + str(ran1) + '?')
-KR