From what I recall, and this is from a few years back, I had to make sure my hosting app was x86. This was my initialization sequence:
Cef.EnableHighDPISupport();
CefSettings settings = new CefSettings();
settings.CachePath = "[somePath]\cache");
settings.RemoteDebuggingPort = 8088;
Cef.Initialize(settings);
browser = new ChromiumWebBrowser("www.google.com");
and hooking up some events and registering a .NET object:
browser.FrameLoadEnd += OnPageLoaded;
browser.LoadError += OnLoadError;
browser.ConsoleMessage += OnConsoleMessage;
browser.RegisterJsObject("dotNet", scriptObject);
and don't forget before you exit:
Cef.Shutdown();
Hope that helps!