Try something like this:
Using con As New SqlConnection(strConnect)
con.Open()
Using cmd As New SqlCommand("INSERT INTO myTable (myColumn1, myColumn2) VALUES (@C1, @C2)", con)
cmd.Parameters.AddWithValue("@C1", myValueForColumn1)
cmd.Parameters.AddWithValue("@C2", myValueForColumn2)
cmd.ExecuteNonQuery()
End Using
End Using