CREATE TABLE yourtable
([ID] int, [User] varchar(10), [Department] varchar(8))
;
INSERT INTO yourtable
([ID], [User], [Department])
VALUES
(1, 'User1', 'Admin'),
(2, 'User1', 'Accounts'),
(3, '1User2', 'Finance'),
(4, 'User3', 'Sales'),
(5, '123User3', 'Finance')
;
select distinct REPLACE(REPLACE(REPLACE(t.[user], '1', ''), '2', ''), '3', '')
from yourtable t;
Try it out online on:
SQL Fiddle[
^]