Basically, you can't.
You can validate that the email address is a valid format address - there are loads of regexes to do just that:
http://www.regular-expressions.info/email.html[
^]
But you can't check that an email exists and is monitored except by sending an email and getting a reply. There is no commonly used mechanism for rejecting an email as "unknown recipient" - though some systems do do just that many, many more don't do anything - and unless the user reads your email and responds you would never know if the email was received. (I have a DontSendMeAnyCrap@MyDomain.com address that is totally valid, but it auto-deletes everything that it receives for example).
The main problem is that spammers and phishers want to know "real" email addresses - so they only send their rubbish to them - and to prevent that most systems just "swallow" duff addresses and delete the email content.
As a result, you can't do it either.