error : ORA-00911:Invalid character can anyone helpout?

strb.Append(" INSERT INTO  PR_JOB_APP_STATUS_DET " & _
                                   " (ID,PR_JOB_APP_STATUS_ID,PR_EMPLOYEE_MASTER_ID,FIRST_NAME,MIDDLE_NAME,LAST_NAME,EMAIL_ID, " & _
                                  " Mobile_No,FILE_PATH,JOB_APP_STATUS,STATUS_DATE,REMARKS) " & _
                                   " VALUES ( " & _
                                   Trim(t_Id) & "," & _
                                   (hdnJobStatID.Value) & "," & _
                                   Trim(t_EmpMasterID) & ",'" & _
                                   Trim(t_First_Name) & "','" & _
                                   Trim(t_Middle_Name) & "','" & _
                                   Trim(t_Last_Name) & "','" & _
                                   Trim(t_Email) & "','" & _
                                   Trim(t_Mobile_No) & "','" & _
                                   Trim(t_File_Path) & "','" & _
                                   Trim(RadISR.SelectedValue) & "'," & _
                                   RsmartUtl.UDSysDate() & ",'" & _
                                   Trim(txtRemarks.Text) & "'" & "); ")
                 

                    If strb.ToString <> "BEGIN" Then
                        'strb.Append(" END; ")
                        MyCmd.Transaction = MyTrans
                        MyCmd.CommandText = strb.ToString
                        MyConn = New OleDbConnection("User Id=erponnet;Password=erponnet;Data Source=RSMARTDEVDB;Provider=OraOLEDB.Oracle")
                        MyConn.Open()
                        MyCmd.Connection = MyConn
                        MyCmd.ExecuteNonQuery()
                        MyConn.Close()

                        'MyCmd = New OleDbCommand(strb.ToString(), MyConn)
                        'MyCmd.Transaction = MyTrans
                        'MyCmd.ExecuteNonQuery()
                        'MyTrans.Commit()
                    End If