How do I match grid values with excel values and retrieve the value of the intersection cell to the grid

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MS-Excel

Hi. Having a grid with with, let's say, the A column and 1 line filled with headers and an excel sheet with the same headers but with values in all other cells is it possibly to match two values from the grid with the same two values from the excel sheet and retrieve the corresponding value from the excel to the grid? Let's say the pair line 3 column E of the grid match Excel sheet's Line 1 column B, can we copy excel's B1 cell value to the grids E3 cell?

Hope it's not too confusing.

Thank you!