You can make use of JQuery which is as simple as
<script type="text/javascript">
$(document).ready(function () {
$("#txtpopup").on("mouseover mouseout", function () {
$("#test").toggle();
});
});
</script>
<asp:TextBox ID="txtpopup" runat="server" ClientIDMode ="static" ></asp:TextBox>
<div id="test" style="display:none;">This can be designed as popup</div>
Regards..