try..
public static int i = 0;
protected void Page_Load(object sender, EventArgs e)
{
}
protected void Button1_Click(object sender, EventArgs e)
{
i++;
lblMsg.Text = "Clicked"+i.ToString();
}
if you want to reset the value in page load then use..
protected void Page_Load(object sender, EventArgs e)
{
if (!IsPostBack)
{
i = 0;
}
}