how sloved this problem when write in word

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ASP.NET

iam use this code for wire from asp.net in word but run from iis locallhost Observation this error

Object reference not set to an instance of an object.

Line 114:
Line 115:            //System.Reflection.Missing.Value is used here for telling that method to use default parameter values when method execution
Line 116:            oDoc = oWordApplication.Documents.Open(fileName, newTemplate, docType, isVisible, ref missing, ref missing, ref missing, ref missing, ref missing, ref missing,
Line 117:                ref missing, ref missing, ref missing, ref missing, ref missing, ref missing);

when run or excute from vs2012 dont error and right was set-up code with out error
.
im dont whats problem.

var realpath="~/template";
            var filePath = Path.Combine(HttpContext.Current.Server.MapPath("~/template"), Lcourseid.Text + ".doc");
            var oWordApplication = new Application();
            DirectoryInfo dir = new DirectoryInfo(Server.MapPath(realpath));
            foreach (FileInfo files in dir.GetFiles())
            {
                files.Delete();
            }
            // To invoke MyMethod with the default argument value, pass  
            // Missing.Value for the optional parameter.
            object missing = System.Reflection.Missing.Value;

            //object fileName = ConfigurationManager.AppSettings["DocxPath"];@"C:\DocXExample.docx";
            string fileName = @"D:\template1.dot";
            //string fileName1 = @"D:\sss.doc";
            object newTemplate = false;
            object docType = 0;
            object isVisible = true;

            //System.Reflection.Missing.Value is used here for telling that method to use default parameter values when method execution
            oDoc = oWordApplication.Documents.Open(fileName, newTemplate, docType, isVisible, ref missing, ref missing, ref missing, ref missing, ref missing, ref missing,
                ref missing, ref missing, ref missing, ref missing, ref missing, ref missing);
           // usable in earlier versions of Microsoft Word v2003  v11
            if(Convert.ToInt16(oWordApplication.Version) >=11)
            {
             //Sets or returns a Boolean that represents whether a document is being viewed in reading layout view.
              oDoc.ActiveWindow.View.ReadingLayout = false;
           }

            //The active window is the window that currently has focus.If there are no windows open, an exception is thrown.
            //microsoft.office.tools.word.
            oDoc.Activate();

            if (oDoc.Bookmarks.Exists("Title"))
            {
                oDoc.Bookmarks["Title"].Range.Text = "Test Field Entry from webform";
                oDoc.Bookmarks["Address"].Range.Text = "Address Field Entry from webform";
            }

            oDoc.SaveAs(filePath, ref missing);
            oWordApplication.Documents.Close(ref missing, ref missing, ref missing);
            //oWordApplication.Quit(ref SaveChanges, ref missing, ref missing, ref missing);
            ProcessRequest(filePath, Lcourseid.Text);