To use that, you need to have the Access ACE engine V12 installed on your machine, and the correct version for the app you are using: a 64 bit app requires the 64 bit engine; a 32 bit app requires the 32 bit version. You can then use the connections string to construct an OledbConnection object, open it, and use OledbCommand objects to access it as if it was a database.
However, there are simpler ways to read XLSX files:
C# How To Read .xlsx Excel File With 3 Lines of Code[
^] for example.