You can use Jquery to call Web Service:-
$("#txtSearch" ).autocomplete({
source: function(request, response) {
$.ajax({
url: "WebService/search.asmx/SearchResult",
dataType: "json",
contentType: "application/json; charset=utf-8",
type: "POST",
data: "{ 'strKey': '" + request.term + "'}",
success: function (data) {
response($.map(data.d, function(item) {
return {
label: item.FirstColumn,
value: item.SecondColumn
}
}))
},
error: function(XMLHttpRequest, textStatus, errorThrown) {
alert(textStatus);
}
});
},
select: function(event, ui){
event.preventDefault();
$("#txtSearch" ).val(ui.item.label);
},
minLength:2
});
Good luck.