string clickHandler = string.Format("document.body.style.cursor = 'wait'; this.value='Please wait...'; this.disabled = true; {0};",
this.ClientScript.GetPostBackEventReference(btnSave271Daily, string.Empty));
btnSave271Daily.Attributes.Add("onclick", clickHandler);
Paste this into PageLoad()
it is working perfectly in IE.
Thank you everyone for your helps.