I found
this[
^] on stackoverflow:
You could setup folder security to prevent the user's from accessing/deleting from the drive.
Give the application a set of credentials it can use to access/manipulate the drive.
You could either setup the system to run as a specified user (eg "run as" or have it running as a windows service), or use
impersonation[
^] to impersonate a user credential to access the drive.