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class MyClass
{
   OtherClass _otherClass;
   ...

   public Populate()
   {
      OtherClass _otherClass = new OtherClass(); 

      ...
      // do lots of stuff and Populate _otherClass with stacks of data
      ...
   }

   public void Process()
   {
       if (_otherClass.HasNoData)
           TotallyFreakOut();
   }
}

var thing = new MyClass();
thing.Populate();
thing.Process();