If you don't have strict in server side, it is better to do it in client side through javasript. Here is the code:
ASPX Code:
<a href="#" id="MIS" onmouseover="ShowMIS()" onmouseout="ClrImg()">MIS Department</a>
Javascript Code:
function ShowMIS()
{
document.getElementById("<%=deptImg.ClientID%>").style.display = "block";
document.getElementById("<%=deptImg.ClientID%>").src = "/Images/MIS.jpg";
document.getElementById("<%=lblName.ClientID%>").innerHTML = "MIS Department";
}
function ClrImg()
{
document.getElementById("<%=deptImg.ClientID%>").style.display = "none";
document.getElementById("<%=lblName.ClientID%>").innerHTML = "";
}
Note: Just cross check the image path and set it as per your need.