Wow.
1) Don't use Size to find the size of a form. Use the Width and Height properties.
2) Don't create a New Size just to throw it away after a comparison.
3) You're not changing the Width at all, just the Height, so don't set it again with a new Size.
4) You don't need the "Me" on everything. The code is in the form class, so Me is already implied with all of it. Just Get/Set the properties and call the methods without breaking your M and E keys on the keyboard.
5) Hopefully this code is only called when the button is clicked?!
Simplify this into:
If Height = 274 Then
Height = 458
Else
Height = 274
End If