Try:
byte[] bytes = File.ReadAllBytes(@"D:\Temp\Myfile.doc");
string encode = Convert.ToBase64String(bytes);
using (SqlConnection con = new SqlConnection(strConnect))
{
con.Open();
using (SqlCommand com = new SqlCommand("INSERT INTO myTable (myColumn) VALUES (@ENC)", con))
{
com.Parameters.AddWithValue("@ENC", System.Text.Encoding.ASCII.GetBytes(encode));
com.ExecuteNonQuery();
}
}