Try:
Private Sub SaveAsToolStripMenuItem_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles SaveAsToolStripMenuItem.Click
Dim myStream As Stream
Dim Save As New SaveFileDialog()
Dim myStreamWriter As System.IO.StreamWriter
Save.Filter = "txt files (*.txt)|*.txt|All files (*.*)|*.*"
Save.Title = "Save"
If Save.ShowDialog() = DialogResult.OK Then
myStream = Save.OpenFile()
If (myStream IsNot Nothing) Then
Using myStreamWriter As StreamWriter = New StreamWriter(myStream, True)
myStreamWriter.WriteLine(TextBox1.Text)
myStreamWriter.WriteLine(TextBox2.Text)
myStreamWriter.Close()
myStream.Close()
End Using
End If
End If
End Sub