Disable run certain applications

Hello everyone.
This code below is used to block run certain applications. It works, but to make the effect visible you need to restart the machine.

I would like to do this without having to restart the machine.
How can I do this without a restart?

Is there a possibility of reboot machine without restarting?
Thanks in advance.

private void blockRunApp()
        {
            try
            {
             Registry.SetValue("HKEY_CURRENT_USER\\SOFTWARE\\Microsoft\\Windows\\CurrentVersion\\Policies\\Explorer", "DisallowRun", 1);

            Microsoft.Win32.RegistryKey rkey;
            rkey = Microsoft.Win32.Registry.CurrentUser.CreateSubKey("SOFTWARE\\Microsoft\\Windows\\CurrentVersion\\Policies\\Explorer\\DisallowRun");
            rkey.SetValue("Appname", "App.exe");
            rkey.Close();
            }
            catch
            {

            }
        }