Problem solved. The related code is below:
OleDbDataAdapter adapterRequest = new OleDbDataAdapter("Select * from " + sRequest, dHelp.connectionString2);
OleDbConnection connection = (OleDbConnection)adapterRequest.SelectCommand.Connection;
connection.Open();
OleDbCommandBuilder cb = new OleDbCommandBuilder(adapterRequest);
DataTable dtTarget = new DataTable();
adapterRequest.Fill(dtTarget);
...
dtTarget.Rows[intRowNo][dtTarget.Columns["AssignedBy"].ColumnName] = TextBoxAssigner.Text;
...
adapterRequest.UpdateCommand = cb.GetUpdateCommand();
adapterRequest.Update(dtTarget);
connection.Close();