I think for that you should bind your combo box like your primary key value should be bind as a value member and the main thing that you want to display in combo box that should be bind as display member so later on you can directly point to the primary key like....
this.cboClients.DataSource = ds.Tables["tableName"];
this.cboClients.DisplayMember = "FieldName";
this.cboClients.ValueMember = "FieldName";
private void cmdEdit_Click(object sender, EventArgs e)
{
string strField = this.cboClients.ValueMember;
int intClient = this.cboClients.SelectedValue;
}