There has to be some form of posting back to the server in order to trigger an activity. The two HTTP verbs of most interest to you here are POST and GET. Even techniques such as using AJAX use these to communicate back with the web server.
By any chance, are you referring to avoiding having to perform an ASP.NET postback operation? If you are, then you can use AJAX to communicate with the server side method. I demonstrate the client side of using AJAX in my article,
A Whistle-stop Tour of jQuery[
^] (look for the section marked "It doesn't just support Dutch football" for details). I haven't covered the server side in my answer here because I have no idea what technology your server side stack is (i.e. is it plain ASP.NET or MVC).