You should use dynamic sql query for that.. :)
like this,
declare @StrQuery nvarchar(max),@columnName varchar(150),@searchText nvarchar(max)
select @StrQuery='select * from tableName where '+@columnName+' like ''%' + @searchText+ '%'''
exec(@StrQuery)
where
@columnName
has been passed from code behind from combobox and
@searchText
has been passed from textbox from code behind.. :)