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I would run a Malwarebytes scan - it's free to download and use. See if that turns up anything.
In the past antivirus applications could have big foot prints although I think that has now been fixed - however it would also be worth opening up the task manager to see if anything is hogging the cpu/memory/disk.
“That which can be asserted without evidence, can be dismissed without evidence.”
but is it [also] a touch screen? (noticed you said mouse, but a lot of ppl with large [glossy] touch screens use a mouse as they dislike the screen smudges and/or sitting so close.)
anyhoo, I remember a ways back for a client finding out that some [older] touch screen all-in-1's did that jerky motion thing when people used a normal mouse but left the touch screen enabled too (even though nothing came near the screen.)
Go to Device Manager...
Look under Human Interface Devices...
You should see one called HID-compliant touch screen.
Right-click it and choose "Disable device".
I had to do this on one laptop (which has a touchscreen) at one point.
Does it happen to be an HP? My wife's HP AIO is a real POS. It had repeatedly had issues installing Win10 updates, repeatedly applying, failing, and rolling back. I had to use system restore to get it back to a usable state, then disable the wireless NIC and touchscreen. This let it get through the WU and seemed to solve some of the sketchy behavior such as losing keystrokes and randomly shifting focus to the windows start button. Also, it was losing focus on the login screen. (while typing the password...quite aggravating!) She hasn't complained about it since, so I can only assume those annoyances have been fixed, or she's just tired of complaining. (I'd bet money on the former!) Good luck!
Try disabling all apps scheduled to launch at startup. Squashing them is a big chunk of safe mode, if that works you can either reenable 1 at a time until you find the offender, or do a binary search-esque (ie enable the top half, does the problem occur...) sweep to narrow it down to the guilty party.
Did you ever see history portrayed as an old man with a wise brow and pulseless heart, weighing all things in the balance of reason?
Is not rather the genius of history like an eternal, imploring maiden, full of fire, with a burning heart and flaming soul, humanly warm and humanly beautiful?
Training a telescope on one’s own belly button will only reveal lint. You like that? You go right on staring at it. I prefer looking at galaxies.
-- Sarah Hoyt
I had a problem like this with the 1803 update on one of my machines. After the update, my one USB mouse turned into 3 USB mice. Basically all my USB devices were now triplets! This computer was just being used as a SageTV client so I just did a fresh install of Win 10 to fix it.
I have had a number of occasions recently when building a project*, that VS stops and kills Windows completely. The mouse cursor disappears, the text caret stops flashing and even Ctrl-Alt-Del does not work. The only way to get out of it is to power off and on again.
*I think it only happens when I press F5 to build and debug. And the code itself is not exactly complicated.