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I second the motion for InnoSetup!
I would recommend it over any of the other tools because it is a lot easier to use.
I've used InstallShield, InsallShieldLE, and the old (VStudio 2008 and before) built-in package creator (whatever that thing was) and InnoSetup is consistently the best, easiest and most reliable.
You can learn it quickly and it consistently works.
However, the one issue is that InnoSetup cannot generate an MSI.
Sometimes that is a problem.