C#

Rectangle rect = New Rectangle(0,0,0,0);
Bitmap myBitmap;

private void PictureBox_MouseDown(object sender, MouseEventArgs e)
{
  if (myBitmap == null)
  {
    myBitmap = New Bitmap(PictureBox1.Width, PictureBox1.Height, PictureBox1.CreateGraphics());
    PictureBox1.Image = myBitmap;
  }

  rect = New Rectangle(e.X, e.Y, 0, 0);
  PictureBox1.Invalidate();
}

private void PictureBox_MouseMove(object sender, MouseEventArgs e)
{
  if (e.Button == MouseButtons.Left)
  {
    rect = New Rectangle(rect.Left, rect.Top, e.X - rect.Left, e.Y - rect.Top);
    PictureBox1.Invalidate();
  }
}

private void PictureBox_Paint(object sender, PaintEventArgs e)
{
    if (myBitmap == null) { return; }

    using (Pen pen = New Pen(Color.Red, 2))
    {
      using (Graphics g = Graphics.FromImage(myBitmap))
      {
        g.Clear(Color.White);
        g.DrawRectangle(pen, rect);
      }
    }
}

private void saveToolStripMenuItem_Click(object sender, EventArgs e)
{
  if (myBitmap != null)
  {
    myBitmap.Save("D:\\Temp\\Bitmapsave.bmp", System.Drawing.Imaging.ImageFormat.Bmp);
  }
}

Image backgroundImage;
Bitmap userDraw;
Rectangle rect;

private void OpenMenuItem()
{
  //Get Image to open

  backgroundImage = new Image(file);
  pictureBox1.Image = backgroundImage;
  pictureBox1.Invalidate();
}

private void pictureBox_MouseDown()
{
  if (userDraw == null)
  {
    userDraw = new Bitmap(pictureBox1.Width, pictureBox1.Height, pictureBox1.CreateGraphics());
  }

  rect = new Rectangle(e.X, e.Y, 0, 0);
  pictureBox1.Invalidate();
}

private void pictureBox_MouseMove()
{
  if (e.Button == MouseButtons.Left)
  {
    rect = new Rectangle(rect.Left, rect.Top, e.X - rect.Left, e.Y - rect.Top);
    pictureBox1.Invalidate();
  }
}

private void PictureBox_Paint(object sender, PaintEventArgs e)
{
    if (myBitmap == null) { return; }

    using (Pen pen = new Pen(Color.Red, 2))
    {
      using (Graphics g = Graphics.FromImage(myBitmap))
      {
          g.Clear(Color.Transparent);

          g.DrawRectangle(pen, rect);
      }
      e.Graphics.DrawRectangle(pen, rect);
    }
}

private void SaveMenuItem()
{
  if (myBitmap != null)
  {
      using (Graphics g = Graphics.FromImage(BackgroundImage))
      {
          g.DrawImage(myBitmap, 0, 0);
      }

      BackgroundImage.Save("C:\\Temp\\Bitmapsave.bmp", System.Drawing.Imaging.ImageFormat.Bmp);
  }
}

Image bac;
Bitmap myBitmap;
private void pictureBox1_MouseDown(object sender, MouseEventArgs e)
{
            if (mybitmap == null)
            {
                mybitmap = new Bitmap(pictureBox1.Width, pictureBox1.Height, pictureBox1.CreateGraphics());

            }
               
            rect = new Rectangle(e.X, e.Y, 0, 0);
             this.Invalidate();
                
}


private void pictureBox1_MouseMove(object sender, MouseEventArgs e)
{

             
               switch (e.Button)
      {
                case MouseButtons.Left:
           {
                    rect = new Rectangle(rect.Left, rect.Top, e.X - rect.Left, e.Y - rect.Top);
                    this.Invalidate();
         
                break;
            }

       }
}
private void pictureBox1_Paint(object sender, PaintEventArgs e)
{

            if (mybitmap == null)
            {
                return;
            }
            using (Pen pen = new Pen(Color.Red, 2))
            {
                using (Graphics g = Graphics.FromImage(mybitmap))
                {
                e.Graphics.DrawRectangle(pen, rect);
                    
                 if (label1.TextAlign == ContentAlignment.TopLeft)
                    {
                        e.Graphics.DrawString(label1.Text, label1.Font, new SolidBrush(label1.ForeColor), label1.Bounds); 
                        g.DrawString(label1.Text, label1.Font, new SolidBrush(label1.ForeColor), label1.Bounds);
mybitmap.PixelFormat);
                    }
                    else if (label1.TextAlign == ContentAlignment.TopCenter)
                    {
                        SizeF size = e.Graphics.MeasureString(label1.Text, label1.Font);
                        float left = ((float)this.Width + label1.Left) / 2 - size.Width / 2;
                        RectangleF rect1 = new RectangleF(left, (float)label1.Top, size.Width, label1.Height);
                        e.Graphics.DrawString(label1.Text, label1.Font, new SolidBrush(label1.ForeColor), rect1);

                    }
                    else
                    {
                        SizeF size = e.Graphics.MeasureString(label1.Text, label1.Font);
                        float left = (float)label1.Width - size.Width + label1.Left;
                        RectangleF rect1 = new RectangleF(left, (float)label1.Top, size.Width, label1.Height);
                        e.Graphics.DrawString(label1.Text, label1.Font, new SolidBrush(label1.ForeColor), rect1);
                    }

               }

        }
            
}

private void saveToolStripMenuItem_Click(object sender, EventArgs e)
{


            if (mybitmap != null)
            {
                SaveFileDialog SaveFD1 = new SaveFileDialog();
                SaveFD1.FileName = "";
                SaveFD1.InitialDirectory = "C";
                SaveFD1.Title = "save file Name";
                SaveFD1.Filter = "JPG|*.jpg|Bmp|*.bmp";
                 if (SaveFD1.ShowDialog() == DialogResult.OK)
                {
                    
                    System.IO.Stream filename = (System.IO.FileStream)SaveFD1.OpenFile();

                    int r = SaveFD1.FileName.Length;
                    for (int r1 = 0; r1<=r;)
                    {
                        if (SaveFD1.FileName[r1] != '.')
                            r1++;
                        else
                        {
                            r = r1;
                            break;
                        }
                    }
                    
                       if (SaveFD1.FileName[++r] == 'j')
                        {
                            using (Graphics g = Graphics.FromImage(bac))
                        {
                           g.DrawImage(mybitmap, 0, 0);
                        }
                        bac.Save(filename, ImageFormat.Jpeg);
                        }
                        else if (SaveFD1.FileName[r] == 'b')
                        {
                            using (Graphics g = Graphics.FromImage(bac))
                            {
                                g.DrawImage(mybitmap, 0, 0);
                            }
                            bac.Save(filename, ImageFormat.Jpeg);
                        }
                        else
                        {
                            using (Graphics g = Graphics.FromImage(bac))
                            {
                                g.DrawImage(mybitmap, 0, 0);
                            }
                            bac.Save(filename, ImageFormat.Png);
                        }
                    
                    filename.Close();

                }
            }
        }

private void openToolStripMenuItem_Click(object sender, EventArgs e)
{

            OpenFD.FileName = "";
            OpenFD.Title = "open image";
            OpenFD.InitialDirectory = "C";
            OpenFD.Filter = "JPEG|*.jpg|Bmp|*.bmp|All Files|*.*.*";
            if (OpenFD.ShowDialog() == DialogResult.OK)
            {
                file = OpenFD.FileName;
                
                bac = Image.FromFile(file);
                pictureBox1.Image = bac;
                pictureBox1.Invalidate();
                

            }

        }