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5teveH wrote: I'm pretty sure that the trials would be rigorous enough to not be skewed by false positives.
That is how science should be done (and how I was taught to do it). Unfortunately, as science moves further from the esoteric (my world) and into the sell-able (as in medical) then, well, you can only hope.
The false-positive that sent my son & family for tests was with the "quick test", which is notoriously unreliable. The second round of testing on the source and his family was a proper test.
An important truth that, by and large, the general public is unaware of is that almost all science that manipulates real materials includes those error-bars. You do experiments, give results, and you also give information in how confident you are in the results (or, in parallel, what fraction of the sample will be transformed to the desired product - rarely 100%). Seeing only the end products, consumers live in a world of near certainty.
| Ravings en masse^ |
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| "The difference between genius and stupidity is that genius has its limits." - Albert Einstein | | "If you are searching for perfection in others, then you seek disappointment. If you seek perfection in yourself, then you will find failure." - Balboos HaGadol Mar 2010 |
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GuyThiebaut wrote:
The UK ONS refuse to answer the question False positivity rate of the COVID-19 PCR test
What?
The answer is right there in the text you linked "specificity is above 99.9%".
So, less than 0.1%
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Read that full paragraph again.
“That which can be asserted without evidence, can be dismissed without evidence.”
― Christopher Hitchens
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The paragraph you got that number from.
I am replying from my mobile so I am not up for typing a whole exposition on how that paragraph is illustrating a scenario.
There is some ambiguity in the paragraph and room for interpretation:
Quote: The results show that when we consider that the sensitivity of the test could... and specificity is above 99.9%
I am reading that as "if we let the sensitivity = x and specificity be above 99.9%"
But I do see that it can also be read as "the sensitivity = x and specificity is above 99.9%"
“That which can be asserted without evidence, can be dismissed without evidence.”
― Christopher Hitchens
modified 25-Mar-21 12:00pm.
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Well, it's admittedly not the clearest way of writing as such.
I suppose they don't want to be overly specific.
The numbers from the manufacturers are way better than that (98-99.8 sensitivity and >99.9 specificity if I recall correctly), but that's marketing.
NHS made a control study[^] together with Porton Down and Oxford, that found those numbers to be a bit lower in reality.
But again, that study is a bit old and the PCR tests are better today.
Also, to address the question you had in your original post: If someone in a trial is testing positive they are retested some days later, not only to lower the chance of false positives but also because the vaccines themselves may cause a positive test.
Apparently they don't, but they couldn't be 100% sure about that when they made the trials.
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Thanks for that information.
“That which can be asserted without evidence, can be dismissed without evidence.”
― Christopher Hitchens
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Pretty good video - maybe because the final point is one I've posted a lot of times: if I'm protected from severe illness then I'm OK with it.
For one of their presentations, however, I take some exception. They present the J&J as basically being tried under more infectious conditions and that contributed to it's apparent lower efficacy. It led one, via numerous implications, that one was "comparing apples and oranges". By implication.
I suggest one think about how the efficacy is calculated: it's a relative calculation within groups of tests. A ratio. Even in less infections conditions, since it's a ratio the differences basically cancel out. It's not a factor to be completely ignored, but, the effect is really reflect in the error-bars as with absolute smaller number in both vaccine and placebo groups in tests under less infections condition. The different variants are another effect.
But, repeating myself, the final conclusion (even though the video is sort of a sales pitch to taken anything you can get - don't worry) is that prevention of a serious outcome is, indeed, the point.
| Ravings en masse^ |
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| "The difference between genius and stupidity is that genius has its limits." - Albert Einstein | | "If you are searching for perfection in others, then you seek disappointment. If you seek perfection in yourself, then you will find failure." - Balboos HaGadol Mar 2010 |
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W∴ Balboos, GHB wrote: if I'm protected from severe illness then I'm OK with it.
Yes. Me too.
W∴ Balboos, GHB wrote: For one of their presentations, however, I take some exception. They present the J&J as basically being tried under more infectious conditions and that contributed to it's apparent lower efficacy. It led one, via numerous implications, that one was "comparing apples and oranges". By implication.
I'm, sort of, with you on this. As a born sceptic, I did wonder if J&J commissioned this video! But, even if they did, its probably valid to point out that trials done at different times and in different countries, will give different results. i.e. You shouldn't make a simple comparison of trial data. You need to understand the underlying conditions.
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Every year I find Vera has done a marathon in New York strangely! (11)
"I have no idea what I did, but I'm taking full credit for it." - ThisOldTony
"Common sense is so rare these days, it should be classified as a super power" - Random T-shirt
AntiTwitter: @DalekDave is now a follower!
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Anniversary ?
"I didn't mention the bats - he'd see them soon enough" - Hunter S Thompson - RIP
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Yay! Care to explain? You are up tomorrow either way ... 
"I have no idea what I did, but I'm taking full credit for it." - ThisOldTony
"Common sense is so rare these days, it should be classified as a super power" - Random T-shirt
AntiTwitter: @DalekDave is now a follower!
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Educated guess really, every year is an anniversary, Vera was in there along with NY - didn't bother with the marathon part.
"I didn't mention the bats - he'd see them soon enough" - Hunter S Thompson - RIP
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Every year
I find I
Vera has VERAS (Vera's)
done a marathon RAN
in New York NY
strangely! (anag)
ANNIVERSARY
"I have no idea what I did, but I'm taking full credit for it." - ThisOldTony
"Common sense is so rare these days, it should be classified as a super power" - Random T-shirt
AntiTwitter: @DalekDave is now a follower!
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"I didn't mention the bats - he'd see them soon enough" - Hunter S Thompson - RIP
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All the recent notebook keypads actually come with a very less "key travel". Sometimes rightly called "Chiclet" keys. You are liking this model?
I've been disliking it for so long, as I've been an fan of deep travel keys. But the new notebook I bought, I'm seeing, it takes a lot lesser effort to type. The stress on the fingers are so less.
So I'm officially joining the chiclet bandwagon. 
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I dislike the "zero travel" membrane keyboards but I am quite happy with a millimetre or two travel. And yes, a lot slicker to type on than the ASR-33 I cut my typing teeth on! I can't touch type on a touchscreen, so tablet and phone are hunt'n'peck.
Cheers,
Peter
Software rusts. Simon Stephenson, ca 1994. So does this signature. me, 2012
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Peter_in_2780 wrote: a lot slicker to type on than the ASR-33
Wasn't it great when you could type a message, and if there was someone watching at the other end, you could see the reply printed out at the same speed?
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Partly, this depends upon where one comes from (in terms of learning to type): I actually had real typing classes (a long time ago). The long travel you speak of on a normal keyboard is only a small fraction of what a "real" mechanical typewriter required. One developed some pretty decent finger muscle power. The long travel (somewhere between 10mm and 20mm) was too much but I do like a real keyboard. My work-laptop, Dell M6500, is referred to as a portable work station and has a full size real keyboard - and feels so much better to use than a typical laptop.
I think the tiny keyboards and horrid chicklet keyboards on those after-thought keyboards are, like I said, horrid.
I'm not a "gamer", but if you look at gaming equipment, those guys spend a lot of money on a keyboard with mechanical keys. I would bet they know something
| Ravings en masse^ |
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| "The difference between genius and stupidity is that genius has its limits." - Albert Einstein | | "If you are searching for perfection in others, then you seek disappointment. If you seek perfection in yourself, then you will find failure." - Balboos HaGadol Mar 2010 |
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I agree. Being an old-fashioned touch typist, I normally rest my fingers on the "home" keys. With some low-travel and zero-travel keyboards, the weight of my fingers plus a little vibration causes the keys to activate, leaving strings of "asdfgjkl;" on the screen.
__________________
Lord, grant me the serenity to accept that there are some things I just can’t keep up with, the determination to keep up with the things I must keep up with, and the wisdom to find a good RSS feed from someone who keeps up with what I’d like to, but just don’t have the damn bandwidth to handle right now.
© 2009, Rex Hammock
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So I've started using a VPN to anonymize my internet activities. No particular reason...
Wow, did everyone get upset. My banks, Microsoft, google all have gone bat $hit crazy thinking my account has been hijacked now that they can't track my IP.
Very, very interesting.
Charlie Gilley
<italic>Stuck in a dysfunctional matrix from which I must escape...
"Where liberty dwells, there is my country." B. Franklin, 1783
“They who can give up essential liberty to obtain a little temporary safety deserve neither liberty nor safety.” BF, 1759
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charlieg wrote: So I've started using a VPN
Which VPN app are you using, I want to go that route but there seems to be lots of them so I can't seem to figure out which one is more secure.
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There are reviews out there. I currently use NordVPN but have also used IPVanish and would recommend either one.
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ProtonVPN offers a free plan, somewhat slow. I need to test more as sometimes I get interference from my customer's VPN.
Be aware that many security checks depend on knowing your general (?) location. I suspect they do velocity checks.
In any event, attempting to access your account with a VPN ip may trigger all sorts of "who are you?" checks.
Charlie Gilley
<italic>Stuck in a dysfunctional matrix from which I must escape...
"Where liberty dwells, there is my country." B. Franklin, 1783
“They who can give up essential liberty to obtain a little temporary safety deserve neither liberty nor safety.” BF, 1759
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charlieg wrote: In any event, attempting to access your account with a VPN ip may trigger all sorts of "who are you?" checks.
That is, after all, the point of a having a VPN, is it not ?
| Ravings en masse^ |
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| "The difference between genius and stupidity is that genius has its limits." - Albert Einstein | | "If you are searching for perfection in others, then you seek disappointment. If you seek perfection in yourself, then you will find failure." - Balboos HaGadol Mar 2010 |
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