C#

• You must marshal data from unmanaged to managed to unmanaged to unmanaged to managed (that seems right) in one direction, and vice versa for the other (to call methods on the running object).
• You must P/Invoke many native functions and re-declare several COM interfaces in managed code (see ComImportAttribute for starters) manually since several of these won't interop correctly using VS.NET or tlbimp.exe (like methods that can return S_FALSE, which is still a success code)
• Your adding complexity to a design that will most likely introduce bugs
• You really end up writing a COM client and server in managed code, not taking advantage of the managed features of the CLR.

private void RaiseProgram(object sender, EventArgs args)
{
    if (InvokeRequired)
    {
        object[] objs = new object[]{sender,args};
        this.Invoke(new EventHandler(RaiseProgram),objs);
        return;
    }
			
    textBox1.Text = RunOnce.OtherAttemptCount.ToString();
    if (this.WindowState == FormWindowState.Minimized)
    {
        this.WindowState = FormWindowState.Normal;
    }
    RunOnce.BringFormToFront(this);
}

/// 
/// The main entry point for the application.
///

static Form1 mainWindow = null;

[STAThread]
static void Main() 
{
    // Create a new Timer with Interval set to 2 seconds.
    System.Timers.Timer aTimer = new System.Timers.Timer(2000);
    aTimer.Elapsed += new ElapsedEventHandler(OnTimedEvent);

    // Only raise the event the first time Interval elapses.
    aTimer.AutoReset = false;
    aTimer.Enabled = true;
    mainWindow = new Form1();
    Application.Run(mainWindow);
}

// Specify what you want to happen when the event is raised.
private static void OnTimedEvent(object source, ElapsedEventArgs e) 
{
    if (mainWindow != null)
    {
        mainWindow.button1_Click(mainWindow,EventArgs.Empty);
    }
}

private void button1_Click(object sender, System.EventArgs e)
{
    if (InvokeRequired)    
    {        
        object[] objs = new object[]{sender,e};        
        this.Invoke(new EventHandler(button1_Click),objs);        
        return;    
    }
    Form1 oForm1 = new Form1();
    oForm1.Show();
}