Yes, we can help you. However, for future reference, if you want help solving an error message, step 1 is to post the error message. There are 42,233,543 possible error messages so it helps to give the exact error and not make people guess.
In this case, the error is very simple. You have a single quote in the word "It's", therefore, it is breaking the string. The compiler thinks you want to update the col to be "It" and then you have "'s" and it has no idea what that means. You need to escape your apostrophe with another apostrophe.
UPDATE table SET col='It''s' WHERE col='It'
And the error message would have told you what was going on.