About the window handles thing, Bharat Kumar has answered it as I don't have much information about it.
However to read the Excel content, you need to use the Interop.Excel, you may also need to use Add-in.
Add this namespace :
Using xl = Microsoft.Office.Interop.Excel;
private xl.Application xlApp;
xlApp = Globals.ThisAddin.Application;
xl.WorkBook workbook = xlApp.ActiveWorkbook;
xl.WorkSheet worksheet = workbook.ActiveSheet;
xl.Range usedRange = worksheet.UsedRange;
String value;
foreach(xl.Range rng in usedRange.Cells)
{
value = rng.Value;
}
Let me know if you have any questions.